Karen is a pejorative term for someone as believing themselves to be entitled or demanding beyond the scope of what is appropriate or necessary. The meme evolved to depict white women who uses her privilege to demand her own way at the expense of others.
В русском интернете встречал употребление в похожем смысле термина «Зинка». Интересно, насколько «Зинка» эквивалентна Karen.